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Heightened Measures of Immune Complex and Complement Function and Immune Complex–Mediated Granulocyte Activation in Human Lymphatic Filariasis

Identifieur interne : 004E50 ( Main/Exploration ); précédent : 004E49; suivant : 004E51

Heightened Measures of Immune Complex and Complement Function and Immune Complex–Mediated Granulocyte Activation in Human Lymphatic Filariasis

Auteurs : Prakash Senbagavalli ; Rajamanickam Anuradha ; Vadakkuppattu D. Ramanathan ; Vasanthapuram Kumaraswami ; Thomas B. Nutman ; Subash Babu

Source :

The American Journal of Tropical Medicine and Hygiene [ 0002-9637 ] ; 2011.

RBID : PMC:3122350

Descripteurs français

KwdFr :
- Activation des lymphocytes, Adolescent, Adulte, Adulte d'âge moyen, Complexe antigène-anticorps (sang), Femelle, Filariose lymphatique (immunologie), Granulocytes (immunologie), Humains, Jeune adulte, Mâle, Protéines du système du complément (physiologie), Sujet âgé, Test ELISA.
MESH :
- immunologie : Filariose lymphatique, Granulocytes.
- physiologie : Protéines du système du complément.
- sang : Complexe antigène-anticorps.
- Activation des lymphocytes, Adolescent, Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Sujet âgé, Test ELISA.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Antigen-Antibody Complex (blood), Complement System Proteins (physiology), Elephantiasis, Filarial (immunology), Enzyme-Linked Immunosorbent Assay, Female, Granulocytes (immunology), Humans, Lymphocyte Activation, Male, Middle Aged, Young Adult.
MESH :
- chemical , blood : Antigen-Antibody Complex.
- chemical , physiology : Complement System Proteins.
- immunology : Elephantiasis, Filarial, Granulocytes.
- Adolescent, Adult, Aged, Enzyme-Linked Immunosorbent Assay, Female, Humans, Lymphocyte Activation, Male, Middle Aged, Young Adult.

Abstract

The presence of circulating immune complexes (CICs) is a characteristic feature of human lymphatic filariasis. However, the role of CICs in modulating granulocyte function and complement functional activity in filarial infection is unknown. The levels of CICs in association with complement activation in clinically asymptomatic, filarial-infected patients (INF); filarial-infected patients with overt lymphatic pathologic changes (CPDT); and uninfected controls (EN) were examined. Significantly increased levels of CICs and enhanced functional efficiency of the classical and mannose-binding lectin pathways of the complement system was observed in INF compared with CPDT and EN. Polyethylene glycol–precipitated CICs from INF and CPDT induced significantly increased granulocyte activation compared with those from EN, determined by the increased production of neutrophil granular proteins and a variety of pro-inflammatory cytokines. Thus, CIC-mediated enhanced granulocyte activation and modulation of complement function are important features of filarial infection and disease.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122350

DOI: 10.4269/ajtmh.2011.11-0086
PubMed: 21734131
PubMed Central: 3122350

Affiliations:

Le document en format XML

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<term>Elephantiasis, Filarial (immunology)</term>
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<front><div type="abstract" xml:lang="en"><p>The presence of circulating immune complexes (CICs) is a characteristic feature of human lymphatic filariasis. However, the role of CICs in modulating granulocyte function and complement functional activity in filarial infection is unknown. The levels of CICs in association with complement activation in clinically asymptomatic, filarial-infected patients (INF); filarial-infected patients with overt lymphatic pathologic changes (CPDT); and uninfected controls (EN) were examined. Significantly increased levels of CICs and enhanced functional efficiency of the classical and mannose-binding lectin pathways of the complement system was observed in INF compared with CPDT and EN. Polyethylene glycol–precipitated CICs from INF and CPDT induced significantly increased granulocyte activation compared with those from EN, determined by the increased production of neutrophil granular proteins and a variety of pro-inflammatory cytokines. Thus, CIC-mediated enhanced granulocyte activation and modulation of complement function are important features of filarial infection and disease.</p>
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Heightened Measures of Immune Complex and Complement Function and Immune Complex–Mediated Granulocyte Activation in Human Lymphatic Filariasis

Heightened Measures of Immune Complex and Complement Function and Immune Complex–Mediated Granulocyte Activation in Human Lymphatic Filariasis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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